Common Side Effects of Ceftriaxone (Ceftriaxone
In vitro studies have shown that Ceftriaxone, like some other cephalosporins, can displace bilirubin from serum albumin. Nursing Mothers Low concentrations of Ceftriaxone are excreted in human milk. Coagulation parameters should be monitored frequently, and the dose of the anticoagulant adjusted accordingly, both during and after treatment with Ceftriaxone (see adverse reactions ). Neonates Premature neonates: Ceftriaxone for injection is contraindicated in premature neonates up to a postmenstrual age of 41 weeks (gestational age chronological age). Generic Name: Ceftriaxone sodium, dosage Form: injection, powder, for solution, medically reviewed on Dec 1, 2017.
Common Side Effects of Rocephin (Ceftriaxone) Drug Center
(SEE figure.) note: Do not access vial with syringe. Ceftriaxone has also been used successfully in a limited number of cases of meningitis and shunt infection caused by Staphylococcus epidermidis* and Escherichia coli. Hemolytic Anemia An immune mediated hemolytic anemia has been observed in patients receiving cephalosporin class antibacterials including Rocephin. Skin AND skin structure infections caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans group streptococci, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii, Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis 1 or Peptostreptococcus species. Squeeze and release drip chamber to establish proper fluid level in chamber. Antibacterial Activity Ceftriaxone has been shown to be active against most isolates of the following bacteria, both in vitro and in clinical infections as described in the indications AND usage (1) section: Gram-negative bacteria Acinetobacter calcoaceticus Enterobacter aerogenes Enterobacter cloacae Escherichia coli Haemophilus. Skin and Skin Structure Infections Caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans group streptococci, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis* or Peptostreptococcus species. Reconstitute vials with an appropriate IV diluent (see compatibility AND stability ). Table 2 Urinary Concentrations of Ceftriaxone After Single Dose Administration Dose/Route Average Urinary Concentrations (g/mL) 0-2 hr 2-4 hr 4-8 hr 8-12 hr 12-24 hr 24-48 hr ND Not determined. This is normal and does not affect the solution quality or safety. Clsi document M07-A10, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015. Lidocaine Intravenous administration of ceftriaxone solutions containing lidocaine is contraindicated.
Ceftriaxone (ceftriaxone) dose, indications, adverse
Patients with previous hypersensitivity reactions to penicillin and other beta lactam antibacterial agents may be at greater risk of hypersensitivity to Ceftriaxone (see warnings Hypersensitivity Reactions ). Ceftriaxone has been shown to be compatible with Flagyl IV (metronidazole hydrochloride). Urolithiasis and Post-Renal Acute Renal Failure Ceftriaxone-calcium precipitates in the urinary tract have been observed in patients receiving Rocephin and may be detected as sonographic abnormalities. Close flow control clamp of administration set. Caution should be exercised when Ceftriaxone is administered to a nursing woman. Interaction with Other Antimicrobials In an in vitro study antagonistic effects have been observed with the combination of chloramphenicol and ceftriaxone. Uncomplicated Gonorrhea (cervical/urethral and rectal) Caused by Neisseria gonorrhoeae, including both penicillinase- and nonpenicillinase-producing strains, and pharyngeal gonorrhea caused by nonpenicillinase-producing strains of Neisseria gonorrhoeae. Mean ( SD) ceftriaxone levels in the middle ear reached a peak of 35 ( 12) g/mL at 24 hours, and remained at 19 ( 7) g/mL at 48 hours. Careful medical history is necessary since cdad has been reported to occur over two months after the administration of antibacterial agents. Rocephin is contraindicated in premature neonates (see contraindications ). The color of Rocephin solutions ranges from light yellow to amber, depending on the length of storage, concentration and diluent used. Confirm the activation and admixture of vial contents. Rocephin should not be administered to hyperbilirubinemic neonates, especially prematures (see contraindications ).